Do Vision CIL Methods Transfer to Protein? A Diagnostic Benchmark of Frozen Protein Encoders
Researchers benchmarked nine class-incremental learning (CIL) methods on frozen protein encoders to evaluate their efficacy in protein function annotation.
Protein function annotation requires adapting to new labels without full retraining. This study tests vision-derived CIL techniques across five protein encoder architectures (sequence, structure, and hybrid) to determine how well they handle expanding label spaces while keeping the underlying encoders frozen.